The museum houses an impressive collection of Iloilo’s cultural heritage which includes stone age native pottery; fossils; jewellery; burial sites; trade pottery from China , Annam and Siam; era photos. Mementos and war relics; a British sunken ship; Spanish-era Filipino sculpture; and modern art done by Ilonggo artists and craftsmen.

Museo Iloilo’s permanent exhibit covers the cultural history of Western Visayas from prehistory to contemporary history. Inside is the carbon-q4 dated fossils, the swords and spears of the Mondo tribe of Panay, and the permanent exhibit showing an Ati family.